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A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator

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Abstract

In this work, a novel fluorescent assay was proposed for the ultrasensitive detection of microRNA-21 (miRNA-21) based on the efficient immobilization of protoporphyrin IX (PPIX) as signal indicators in massive G-quadruplex structures obtained by target recycling, three-dimensional DNA walker and a rolling circle amplification (RCA) coupled cascade nucleic acid amplification strategy.

Graphical abstract: A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator

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Publication details

The article was received on 06 Mar 2019, accepted on 01 May 2019 and first published on 02 May 2019


Article type: Communication
DOI: 10.1039/C9CC01850F
Chem. Commun., 2019, Advance Article

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    A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator

    Z. Yang, Z. Wen, X. Peng, Y. Chai, W. Liang and R. Yuan, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01850F

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