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Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

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Abstract

The organocatalytic enantioselective Friedel–Crafts alkylation of phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products. The synthetic utility is demonstrated by the very concise asymmetric total synthesis of aflatoxins B2.

Graphical abstract: Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

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Publication details

The article was received on 06 Mar 2019, accepted on 08 Apr 2019 and first published on 08 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01833F
Citation: Chem. Commun., 2019, Advance Article

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    Organocatalytic enantioselective direct alkylation of phloroglucinol derivatives: asymmetric total synthesis of (+)-aflatoxin B2

    Z. Wang and L. Zu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01833F

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