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Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells

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Abstract

Herein, we have designed a ratiometric fluorescent nanoprobe for adenosine triphosphate sensing and imaging in living cells, based on silica nanoparticles and a DNA-functionalized hybrid hydrogel. This ratiometric detecting method could validly avoid false-positive signals. Due to its controllable size, favorable biocompatibility and biostability, the nanohydrogel exhibited high cellular permeability and fast response in living cells.

Graphical abstract: Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells

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Publication details

The article was received on 12 Mar 2019, accepted on 05 Apr 2019 and first published on 05 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01832H
Citation: Chem. Commun., 2019, Advance Article

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    Size-controlled DNA-cross-linked hydrogel coated silica nanoparticles served as a ratiometric fluorescent probe for the detection of adenosine triphosphate in living cells

    X. Ji, J. Wang, S. Niu and C. Ding, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01832H

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