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General rhodium-catalyzed oxidative cross-coupling reactions between anilines: synthesis of unsymmetrical 2,2’-diaminobiaryls

Abstract

Described herein is a dual chelation-assisted RhCl3-catalyzed oxidative C–H/C–H cross-coupling reaction of aniline derivatives. The highlight of this methodology is the chemo- and regioselective cross-coupling between electronically similar substrates, which represents a highly challenging task in oxidative Ar–H/Ar–H cross-coupling reactions. Furthermore, this Cp*-Free catalytic reaction tolerates a range of functional groups and requires only a low molar ratio of coupling partners. These features expedite the synthesis of unsymmetrical 2,2’-diaminobiaryls.

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Publication details

The article was received on 02 Mar 2019, accepted on 11 Apr 2019 and first published on 12 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01733J
Citation: Chem. Commun., 2019, Accepted Manuscript

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    General rhodium-catalyzed oxidative cross-coupling reactions between anilines: synthesis of unsymmetrical 2,2’-diaminobiaryls

    Y. Shi, J. Liu, Y. Yang and J. You, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC01733J

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