Issue 49, 2019
From the journal:

Chemical Communications

Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells†

Carlos Sanchez-Cano, ORCID logo ‡§*a   Diego Gianolio,‡b   Isolda Romero-Canelon, ORCID logo a   Remi Tucoulouc  and  Peter J. Sadler ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: p.j.sadler@warwick.ac.uk

b Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon, UK

c ESRF, The European Synchrotron, 71 Avenue des Martyrs, Grenoble, France

Abstract

Synchrotron nanoprobe X-ray absorption (XAS) studies of a potent organo-osmium arene anticancer complex in ovarian cancer cells at subcellular resolution allow detection and quantification of both OsII and OsIII species, which are distributed heterogeneously in different areas of the cells.

Graphical abstract: Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

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Article information

DOI
https://doi.org/10.1039/C9CC01675A
Article type
Communication
Submitted
27 Feb 2019
Accepted
01 May 2019
First published
31 May 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 7065-7068

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Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

C. Sanchez-Cano, D. Gianolio, I. Romero-Canelon, R. Tucoulou and P. J. Sadler, Chem. Commun., 2019, 55, 7065 DOI: 10.1039/C9CC01675A

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