Issue 29, 2019
From the journal:

Chemical Communications

A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum†

Olga V. Kuznetsova,a   Irina S. Reshetnikova,b   Sergei N. Shtykov,b   Vasilii K. Karandashev,c   Bernhard K. Kepplerd  and  Andrei R. Timerbaev ORCID logo *a  

* Corresponding authors

a Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow, Russian Federation
E-mail: andrei.timerbaev@univie.ac.at

b Institute of Chemistry, Saratov State University, Saratov, Russian Federation

c Institute of Microelectronics Technology and High-Purity Materials, Chernogolovka, Russian Federation

d Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria

Abstract

A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed. Based on ultrafiltration of a human serum-nanoparticle mixture and the mass spectrometric analysis of filtrates, this assay revealed for iron oxide nanoparticles coated with poly(acrylic acid) satisfactory biopersistence and a bimodal binding to sulfur-containing biomolecules, with the formation of the protein corona completed in about 1 h.

Graphical abstract: A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum

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Article information

DOI
https://doi.org/10.1039/C9CC01642B
Article type
Communication
Submitted
28 Feb 2019
Accepted
18 Mar 2019
First published
18 Mar 2019

Chem. Commun., 2019,55, 4270-4272

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A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum

O. V. Kuznetsova, I. S. Reshetnikova, S. N. Shtykov, V. K. Karandashev, B. K. Keppler and A. R. Timerbaev, Chem. Commun., 2019, 55, 4270 DOI: 10.1039/C9CC01642B

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