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Simple alkanoyl acylating agents for reversible RNA functionalization and control

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Abstract

We describe the synthesis and RNA acylation activity of a series of minimalist azidoalkanoyl imidazole reagents, with the aim of functionalizing RNA at 2′-hydroxyl groups at stoichiometric to superstoichiometric levels. We find marked effects of small structural changes on their ability to acylate and be reductively removed, and identify reagents and methods that enable efficient RNA functionalization and control.

Graphical abstract: Simple alkanoyl acylating agents for reversible RNA functionalization and control

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Publication details

The article was received on 26 Feb 2019, accepted on 03 Apr 2019 and first published on 03 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01598A
Citation: Chem. Commun., 2019, Advance Article

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    Simple alkanoyl acylating agents for reversible RNA functionalization and control

    H. S. Park, A. M. Kietrys and E. T. Kool, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01598A

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