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Issue 34, 2019
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Engineered peptidic constructs metabolize amyloid β by self-assembly-driven reactions

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Abstract

Inspired by the unique mechanism of proteolytic maturation of host cell factor-1, we designed small peptide-based constructs that selectively recognized amyloid β (Aβ) and cleaved it in a non-catalytic manner initially around the α-secretase cleavage-site, thus termed as “artificial α-secretases”. “Artificial α-secretases” also cleaved Aβ on the cleavage-sites of other Aβ processing enzymes by prolonged treatment, as evidenced by time-resolved MALDI-TOF-mass analyses.

Graphical abstract: Engineered peptidic constructs metabolize amyloid β by self-assembly-driven reactions

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Publication details

The article was received on 25 Feb 2019, accepted on 29 Mar 2019 and first published on 01 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01582E
Citation: Chem. Commun., 2019,55, 4933-4936

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    Engineered peptidic constructs metabolize amyloid β by self-assembly-driven reactions

    T. Mondal and B. Mandal, Chem. Commun., 2019, 55, 4933
    DOI: 10.1039/C9CC01582E

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