Jump to main content
Jump to site search

Issue 34, 2019
Previous Article Next Article

PVIM–Co5POM/MNC composite as a flexible electrode for the ultrasensitive and highly selective non-enzymatic electrochemical detection of cholesterol

Author affiliations

Abstract

To address the issues allied with cardiovascular diseases and the increased prevalence of hypertension, a novel electrochemical sensor was developed based on poly(ionic liquid) [PVIM]–cobalt polyoxometalate (Co5POM) supported on carbonaceous materials (MNCs) for the highly selective and ultrasensitive non-enzymatic detection of cholesterol. The novel composite exhibits excellent selectivity and sensitivity towards the non-enzymatic electrochemical detection of cholesterol with a low detection limit of 1 fM (1 × 10−15 M), a response time of ∼5 s, and a wide detection range of 1 fM–5 mM with two linear ranges of 1 fM–200 nM and 0.5 μM–5 mM with sensitivities of 210 and 64 μA μM−1 cm−2, respectively, even in the presence of ascorbic acid, glucose and uric acid. The proposed sensor was tested with a human blood serum sample at physiological pH in a physiologically relevant concentration range. A novel flexible sensor was developed with PVIM–Co5POM/MNC coated over Whatman filter paper and this shows a high sensitivity with a wide detection range of 1 fM–5 mM.

Graphical abstract: PVIM–Co5POM/MNC composite as a flexible electrode for the ultrasensitive and highly selective non-enzymatic electrochemical detection of cholesterol

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Feb 2019, accepted on 22 Mar 2019 and first published on 22 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01534E
Citation: Chem. Commun., 2019,55, 5021-5024

  •   Request permissions

    PVIM–Co5POM/MNC composite as a flexible electrode for the ultrasensitive and highly selective non-enzymatic electrochemical detection of cholesterol

    N. Thakur, M. Kumar, S. Das Adhikary, D. Mandal and T. C. Nagaiah, Chem. Commun., 2019, 55, 5021
    DOI: 10.1039/C9CC01534E

Search articles by author

Spotlight

Advertisements