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Polygemcitabine nanogel with accelerated drug activation for cancer therapy

Abstract

To overcome the slow activation of gemcitabine, we synthesized a DNA-like polygemcitabine (Ge10) strand through solid-phase synthesis, which not only undergoes rapid intracellular degradation to generate active gemcitabine derivatives, but also can self-assemble into nanogels through molecular recognition, rendering them as promising self-delivered nanodrugs for cancer therapy.

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Supplementary files

Publication details

The article was received on 22 Feb 2019, accepted on 08 May 2019 and first published on 13 May 2019


Article type: Communication
DOI: 10.1039/C9CC01506J
Chem. Commun., 2019, Accepted Manuscript

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    Polygemcitabine nanogel with accelerated drug activation for cancer therapy

    Y. Ma, Q. Mou, L. Zhu, Y. Su, X. Jin, J. Feng, D. Yan, X. Zhu and C. Zhang, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC01506J

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