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Issue 45, 2019
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Direct readout protonophore induced selective uncoupling and dysfunction of individual mitochondria within cancer cells

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Abstract

Concurrently, manipulation of mitochondrial activity and its monitoring have enormous significance in cancer therapy and diagnosis. In this context, a fluorescent probe MitoDP has been developed for validating H2S mediated protonophore (2,4-dinitrophenol, DNP) induced mitochondrial membrane potential change, ROS formation and ATP depletion in cancer cells. The extent of protonophore activation for mitochondrial dysfunction is monitored through fluorescence signalling at 450 nm. The current study provides a proof for the concept of endogenous H2S-mediated controlled and spatial release of bioactive agents, or toxins specifically in mitochondria of cancer cells.

Graphical abstract: Direct readout protonophore induced selective uncoupling and dysfunction of individual mitochondria within cancer cells

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Publication details

The article was received on 22 Feb 2019, accepted on 09 May 2019 and first published on 09 May 2019


Article type: Communication
DOI: 10.1039/C9CC01483G
Chem. Commun., 2019,55, 6429-6432

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    Direct readout protonophore induced selective uncoupling and dysfunction of individual mitochondria within cancer cells

    K. N. Bobba, A. Binoy, S. Koo, D. Nedungadi, A. Podder, A. Sharma, N. Mishra, J. S. Kim and S. Bhuniya, Chem. Commun., 2019, 55, 6429
    DOI: 10.1039/C9CC01483G

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