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Light-activated “cycle-reversible intramolecular charge transfer” fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death

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Abstract

Under the synergistic effects of protonation and deprotonation, a light-activated fluorescent probe (UV-SP) exhibited “cycle-reversible intramolecular charge transfer (ICT)” for different pH after activation by UV light, resulting in emission of multiple ratio fluorescent signals (FI563/FI595 and FI664/FI595). Based on these kinds of response signals, UV-SP can specifically monitor the cycle-reversible trace change of intracellular pH caused by UV radiation. More importantly, according to the stable and invariant multiple ratio fluorescent signals, UV-SP can sort cells entering programmed death.

Graphical abstract: Light-activated “cycle-reversible intramolecular charge transfer” fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death

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Publication details

The article was received on 20 Feb 2019, accepted on 01 Apr 2019 and first published on 01 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01451A
Citation: Chem. Commun., 2019, Advance Article

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    Light-activated “cycle-reversible intramolecular charge transfer” fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death

    T. Jiang, X. Wang, G. Wang, Y. Wang, K. Wang, X. Xuan, C. Chen, K. Jiang and H. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01451A

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