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A multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor cells

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Abstract

We report the design and fabrication of a multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor. The integration of the dual-stimulus of an acidic microenvironment and laser irradiation with the triple-synergistic therapy of doxorubicin, photothermal and siRNA offers excellent therapeutic performance for drug resistant tumor cells with high specificity and little side effects.

Graphical abstract: A multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor cells

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Publication details

The article was received on 20 Feb 2019, accepted on 09 Apr 2019 and first published on 09 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01446B
Citation: Chem. Commun., 2019, Advance Article

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    A multifunctional persistent luminescent nanoprobe for imaging guided dual-stimulus responsive and triple-synergistic therapy of drug resistant tumor cells

    F. Su, X. Zhao, C. Dai, Y. Li, C. Yang and X. Yan, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01446B

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