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Hydrogen Atom Abstraction by Synthetic Heme Ferric Superoxide and Hydroperoxide Species

Abstract

Till date artificial dioxygen adducts of heme have not been demonstrated to be able to oxidize organic substrates in sharp contrast to their non-heme analogues and naturally occurring enzymes like heme dioxygenases. To address this apparent anomaly an iron porphyrin complex is synthesized which includes a pendant quinol group. The corresponding dioxygen bound iron porphyrin species is demonstrated to perform Hydrogen atom transfer (HAT) from a quinol group appended to the porphyrin ligand. The resultant ferric peroxide, formed by the first HAT, performs a 2nd HAT generating a ferryl species (FeIV=O) and resulting in the 2e-/2H+ oxidation of the pendant hydroquinol to quinone.

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Publication details

The article was received on 20 Feb 2019, accepted on 11 Apr 2019 and first published on 11 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01423C
Citation: Chem. Commun., 2019, Accepted Manuscript

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    Hydrogen Atom Abstraction by Synthetic Heme Ferric Superoxide and Hydroperoxide Species

    A. Singha and A. Dey, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC01423C

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