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Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

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Abstract

We report the engineering of a protein-based dynamic hydrogel that can be reversibly tuned between stiff and soft states via a redox reaction. When cultured on this hydrogel surface, human lung fibroblasts can dynamically and reversibly change their morphology in response to changes in hydrogel stiffness.

Graphical abstract: Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

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Publication details

The article was received on 14 Feb 2019, accepted on 04 Apr 2019 and first published on 04 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01276A
Citation: Chem. Commun., 2019, Advance Article

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    Dynamic protein hydrogels with reversibly tunable stiffness regulate human lung fibroblast spreading reversibly

    L. Fu, A. Haage, N. Kong, G. Tanentzapf and H. Li, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01276A

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