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Issue 35, 2019
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Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

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Abstract

Monitoring autophagy can provide valuable insights into understanding human pathological mechanisms, developing novel drugs, and exploring autophagy control approaches. Here, we proposed a new strategy to specifically monitor autophagy by lighting up the G-quadruplex structures entering autolysosomes. Based on this strategy, we designed a small-molecule fluorescent probe for autophagy imaging. This work not only opens up a new way for developing autophagy probes, but also provides an effective tool for autophagy research.

Graphical abstract: Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

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Publication details

The article was received on 13 Feb 2019, accepted on 19 Mar 2019 and first published on 19 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01263J
Chem. Commun., 2019,55, 5060-5063

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    Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures

    H. Chen, H. Sun, S. Zhang, W. Yan, Q. Li, A. Guan, J. Xiang, M. Liu and Y. Tang, Chem. Commun., 2019, 55, 5060
    DOI: 10.1039/C9CC01263J

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