Issue 32, 2019
From the journal:

Chemical Communications

DNP NMR spectroscopy reveals new structures, residues and interactions in wild spider silks†

Hamish C. Craig, ORCID logo a   Sean J. Blamires,*a   Marc-Antoine Sani, ORCID logo b   Michael M. Kasumovic,a   Aditya Rawalc  and  James M. Hook ORCID logo *cd  

* Corresponding authors

a School of Biological, Earth and Environmental Science, University of New South Wales, Sydney, Australia
E-mail: sean.blamires@unsw.edu.au

b School of Chemistry/Bio21 Institute, University of Melbourne, Victoria, Australia

c NMR Facility, Mark Wainwright Analytical Centre, Sydney, Australia

d School of Chemistry, University of New South Wales, Sydney, Australia
E-mail: j.hook@unsw.edu.au

Abstract

DNP solid state NMR spectroscopy allows non-targeted analysis of wild spider silk in unprecedented detail at natural abundance, revealing hitherto unreported features across several species. A >50-fold signal enhancement for each silk, enables the detection of novel H-bonding networks and arginine conformations, and the post-translational modified amino acid, hydroxyproline.

Graphical abstract: DNP NMR spectroscopy reveals new structures, residues and interactions in wild spider silks

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Article information

DOI
https://doi.org/10.1039/C9CC01045A
Article type
Communication
Submitted
05 Feb 2019
Accepted
27 Mar 2019
First published
02 Apr 2019

Chem. Commun., 2019,55, 4687-4690

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DNP NMR spectroscopy reveals new structures, residues and interactions in wild spider silks

H. C. Craig, S. J. Blamires, M. Sani, M. M. Kasumovic, A. Rawal and J. M. Hook, Chem. Commun., 2019, 55, 4687 DOI: 10.1039/C9CC01045A

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