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Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity

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Abstract

The extracellular SspA protease of the human pathogen S. aureus is essential for evading the host immune defence system. Two novel FRET probes for selective real-time ratiometric imaging of SspA activity in live S. aureus cells are reported.

Graphical abstract: Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity

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Publication details

The article was received on 01 Feb 2019, accepted on 11 Mar 2019 and first published on 12 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC00953A
Citation: Chem. Commun., 2019, Advance Article

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    Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity

    Q. Wang, X. Wang, Y. Sun, X. Yang, L. Zhang, Q. Zhang, Z. Hu and H. Hu, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC00953A

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