Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration†
Concise, divergent total syntheses of five bioactive illudalane sesquiterpenes have been achieved. Our synthesis features an intermolecular [2+2+2] cycloaddition, and a lactone-directed aromatic C–H oxygenation to generate a temporary phenolic hydroxyl group which enables regioselective methylation. Furthermore, the absolute configuration of radulactone was assigned by chemical synthesis.
- This article is part of the themed collections: Celebrating a Century of Excellency in Chemistry at Xiamen University and Natural product synthesis