Jump to main content
Jump to site search

Issue 33, 2019
Previous Article Next Article

Strong positive allosteric cooperativity in ternary complexes based on hydrogen-bonded aromatic amide macrocycles

Author affiliations

Abstract

Three new hydrogen-bonded aromatic amide macrocycles with eight residues were synthesized. The first single crystal structure of this class of larger macrocycles was obtained, which reveals a saddle-like conformation. Interestingly, in sharp contrast to previous negative cooperativity in binding paraquat with cyclo[6]aramide, strong positive allosteric cooperativity in ternary complexes was observed. This may open an avenue for the construction of mechanically interlocked molecules with these larger H-bonded macrocycles.

Graphical abstract: Strong positive allosteric cooperativity in ternary complexes based on hydrogen-bonded aromatic amide macrocycles

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jan 2019, accepted on 27 Mar 2019 and first published on 28 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC00925F
Citation: Chem. Commun., 2019,55, 4869-4872

  •   Request permissions

    Strong positive allosteric cooperativity in ternary complexes based on hydrogen-bonded aromatic amide macrocycles

    Z. Peng, X. Guo, W. Xu, J. Li, P. Deng, X. Xiao, W. Feng and L. Yuan, Chem. Commun., 2019, 55, 4869
    DOI: 10.1039/C9CC00925F

Search articles by author

Spotlight

Advertisements