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A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

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Abstract

High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.

Graphical abstract: A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

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Publication details

The article was received on 31 Jan 2019, accepted on 07 May 2019 and first published on 10 May 2019


Article type: Communication
DOI: 10.1039/C9CC00923J
Chem. Commun., 2019, Advance Article

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    A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

    S. H. Gilbert, V. Viseur and M. L. Clarke, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC00923J

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