A rational strategy for the facile and efficient cyclization of amino acid-based linear precursors forming nine and twelve-membered cyclic peptidomimetics is reported. The resulting chiral lactams can readily be reduced to substituted cyclic polyamine analogues of 1,4,7,10-tetraaza-cyclododecane (cyclen) and 1,4,7-triaza-cyclononane (TACN).
T. Müntener, F. Thommen, D. Joss, J. Kottelat, A. Prescimone and D. Häussinger, Chem. Commun., 2019, 55, 4715 DOI: 10.1039/C9CC00720B
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