Jump to main content
Jump to site search


C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F

Author affiliations

Abstract

This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.

Graphical abstract: C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jan 2019, accepted on 12 Feb 2019 and first published on 12 Feb 2019


Article type: Communication
DOI: 10.1039/C9CC00641A
Citation: Chem. Commun., 2019, Advance Article

  •   Request permissions

    C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F

    S. J. Lee, A. F. Brooks, N. Ichiishi, K. J. Makaravage, A. V. Mossine, M. S. Sanford and P. J. H. Scott, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC00641A

Search articles by author

Spotlight

Advertisements