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Issue 30, 2019
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Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

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Abstract

Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-O-methyltransferase and the N-methyl-D-aspartate receptors have been predicted, including both binding regions and related conformational changes.

Graphical abstract: Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

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Supplementary files

Article information


Submitted
21 Jan 2019
Accepted
21 Feb 2019
First published
22 Feb 2019

Chem. Commun., 2019,55, 4311-4314
Article type
Communication

Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling

Y. Zhou, Z. Liu, J. Zhang, T. Dou, J. Chen, G. Ge, S. Zhu and F. Wang, Chem. Commun., 2019, 55, 4311
DOI: 10.1039/C9CC00520J

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