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Trimethine cyanine dyes as deep-red fluorescent indicators with high selectivity to the internal loop of the bacterial A-site RNA

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Abstract

We report that TO-PRO-3, a thiazole orange analogue with a trimethine bridge, functions as a deep-red fluorescent indicator for the internal loop structure of the bacterial (Escherichia coli) ribosomal decoding region of the aminoacyl-tRNA site (A-site), which enables the assessment of A-site binding capability of various test compounds including blue and even-green-emitting compounds.

Graphical abstract: Trimethine cyanine dyes as deep-red fluorescent indicators with high selectivity to the internal loop of the bacterial A-site RNA

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Publication details

The article was received on 17 Jan 2019, accepted on 29 Jan 2019 and first published on 30 Jan 2019


Article type: Communication
DOI: 10.1039/C9CC00414A
Citation: Chem. Commun., 2019, Advance Article

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    Trimethine cyanine dyes as deep-red fluorescent indicators with high selectivity to the internal loop of the bacterial A-site RNA

    Y. Sato, S. Yajima, A. Taguchi, K. Baba, M. Nakagomi, Y. Aiba and S. Nishizawa, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC00414A

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