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Issue 60, 2019
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A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

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Abstract

We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

Graphical abstract: A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

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Supplementary files

Article information


Submitted
15 Jan 2019
Accepted
13 Jun 2019
First published
13 Jun 2019

Chem. Commun., 2019,55, 8860-8863
Article type
Communication

A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860 DOI: 10.1039/C9CC00375D

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