Issue 18, 2019
From the journal:

Chemical Communications

Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus†

Jia-fu Lin,‡a   Juan Li,‡a   Ashna Gopal, ORCID logo b   Tasnim Munshi,c   Yi-wen Chu,a   Jiang-xia Wang,a   Ting-ting Liu,a   Bingyang Shi, ORCID logo d   Xianfeng Chen ORCID logo *b  and  Li Yan ORCID logo *ae  

* Corresponding authors

a Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University, Chengdu, Sichuan, P. R. China
E-mail: tony_yan8@hotmail.com, tony.yan@monash.edu

b School of Engineering, Institute for Bioengineering, The University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, UK
E-mail: xianfeng.chen@oxon.org, Michael.Chen@ed.ac.uk

c School of Chemistry, University of Lincoln, Brayford Pool, Lincoln, UK

d Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia

e Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

Abstract

Multidrug resistant bacterial infection remains a significant public concern. In this report, photosensitizer Chlorin e6 doped silica was synthesized. This hybrid structure exhibits enhanced photostability and high antibacterial efficiency towards Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). In summary, this work demonstrates an effective platform to improve the efficiency of antibiotics for better treatment of wound infections.

Graphical abstract: Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus

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Article information

DOI
https://doi.org/10.1039/C9CC00166B
Article type
Communication
Submitted
08 Jan 2019
Accepted
30 Jan 2019
First published
31 Jan 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 2656-2659

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Synthesis of photo-excited Chlorin e6 conjugated silica nanoparticles for enhanced anti-bacterial efficiency to overcome methicillin-resistant Staphylococcus aureus

J. Lin, J. Li, A. Gopal, T. Munshi, Y. Chu, J. Wang, T. Liu, B. Shi, X. Chen and L. Yan, Chem. Commun., 2019, 55, 2656 DOI: 10.1039/C9CC00166B

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