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Issue 16, 2019
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Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity

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Abstract

An indole-rich tripodal microtubule inhibitor is designed, which binds at the DCVJ site of tubulin and inhibits its polymerization. It causes apoptotic death of cancer cells without affecting normal cells and inhibits the growth of tumors. Finally, STD-NMR and TR-NOESY experiments reveal that the indole appendages play a crucial role in interacting with tubulin.

Graphical abstract: Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity

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Publication details

The article was received on 04 Jan 2019, accepted on 25 Jan 2019 and first published on 25 Jan 2019


Article type: Communication
DOI: 10.1039/C9CC00074G
Citation: Chem. Commun., 2019,55, 2356-2359

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    Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity

    S. Barman, G. Das, P. Mondal, K. Pradhan, B. Jana, D. Bhunia, A. Saha, C. Kar and S. Ghosh, Chem. Commun., 2019, 55, 2356
    DOI: 10.1039/C9CC00074G

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