Issue 18, 2019
From the journal:

Chemical Communications

Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis†

Sinyoung Jeong,‡a   Homan Kang,§b   Myeong Geun Cha,a   Sung Gun Lee,a   Jaehi Kim,b   Hyejin Chang, ORCID logo c   Yoon-Sik Leeb  and  Dae Hong Jeong ORCID logo *ad  

* Corresponding authors

a Department of Chemistry Education, Seoul National University, Seoul, Republic of Korea
E-mail: jeongdh@snu.ac.kr

b School of Chemical & Biological Engineering, Seoul National University, Seoul, Republic of Korea

c Department of Science Education, Kangwon National University, Chuncheon, Republic of Korea

d Center for Educational Research, Seoul National University, Seoul 08826, Republic of Korea

Abstract

We developed a ready-to-read on-bead peptide encoding method for high-throughput screening bioassays. With two-dimensional surface-enhanced Raman scattering nano-identifiers (2D-SERS IDs) which are concurrently labelled with two SERS codes (coupling steps and kinds of amino acid), we could possibly generate more than 10 trillion codes with only 30 Raman label compounds.

Graphical abstract: Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

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Article information

DOI
https://doi.org/10.1039/C8CC10224D
Article type
Communication
Submitted
27 Dec 2018
Accepted
30 Jan 2019
First published
13 Feb 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 2700-2703

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Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

S. Jeong, H. Kang, M. G. Cha, S. G. Lee, J. Kim, H. Chang, Y. Lee and D. H. Jeong, Chem. Commun., 2019, 55, 2700 DOI: 10.1039/C8CC10224D

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