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Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

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Abstract

We developed a ready-to-read on-bead peptide encoding method for high-throughput screening bioassays. With two-dimensional surface-enhanced Raman scattering nano-identifiers (2D-SERS IDs) which are concurrently labelled with two SERS codes (coupling steps and kinds of amino acid), we could possibly generate more than 10 trillion codes with only 30 Raman label compounds.

Graphical abstract: Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

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Publication details

The article was received on 27 Dec 2018, accepted on 30 Jan 2019 and first published on 13 Feb 2019


Article type: Communication
DOI: 10.1039/C8CC10224D
Citation: Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY-NC license
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    Two-dimensional SERS encoding method for on-bead peptide sequencing in high-throughput bioanalysis

    S. Jeong, H. Kang, M. G. Cha, S. G. Lee, J. Kim, H. Chang, Y. Lee and D. H. Jeong, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC10224D

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