We have formulated 7-ethyl-10-hydroxy camptothecin (SN38) nanocrystals using a novel combination of reversible reactions and pharmaceutical technology. The nanocrystals are taken up more efficiently by cells and accumulate more in tumors than the commercially available camptothecin compound irinotecan (CPT-11), leading to superior anti-tumor efficacy in vitro and in vivo.
Q. Yang, T. Tan, J. Zhao, C. Zhou, C. Guo, Z. Wan, X. Song and T. Gong, Chem. Commun., 2019, 55, 3144 DOI: 10.1039/C8CC10191D
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