Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 21, 2019
Previous Article Next Article

Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Author affiliations

Abstract

Enantiodiscriminative helix formation was observed for β-peptide H14 helices. This observation is caused by the synperiplanar orientation of H–O atoms which is more unfavorable than those for H–H interaction. The 1,2 H–O interaction leads to the destruction of the helical structure. The introduction of a double C–C bond in the backbone rules out helix formation.

Graphical abstract: Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

Back to tab navigation

Supplementary files

Article information


Submitted
22 Dec 2018
Accepted
25 Jan 2019
First published
25 Jan 2019

Chem. Commun., 2019,55, 3061-3064
Article type
Communication

Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation

I. Nekkaa, D. Bogdán, T. Gáti, S. Béni, T. Juhász, M. Palkó, G. Paragi, G. K. Tóth, F. Fülöp and I. M. Mándity, Chem. Commun., 2019, 55, 3061
DOI: 10.1039/C8CC10147G

Social activity

Search articles by author

Spotlight

Advertisements