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Issue 40, 2019
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The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

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Abstract

Giant unilamellar protein vesicles (GUPs) were formed with the adenosine A2A receptor (A2AR) incorporated in the lipid bilayer and protein partitioning into the liquid ordered and liquid disordered phases was observed. When no ligand is bound, A2AR partitions preferentially into the liquid disordered phase of GUPs, while ligand-bound A2AR partitions into the liquid ordered phase.

Graphical abstract: The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

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Publication details

The article was received on 21 Dec 2018, accepted on 17 Apr 2019 and first published on 30 Apr 2019


Article type: Communication
DOI: 10.1039/C8CC10130B
Chem. Commun., 2019,55, 5724-5727

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    The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state

    M. G. Gutierrez, J. Deyell, K. L. White, L. C. Dalle Ore, V. Cherezov, R. C. Stevens and N. Malmstadt, Chem. Commun., 2019, 55, 5724
    DOI: 10.1039/C8CC10130B

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