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Issue 17, 2019
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Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

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Abstract

A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time.

Graphical abstract: Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

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Publication details

The article was received on 20 Dec 2018, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC10084E
Citation: Chem. Commun., 2019,55, 2477-2480

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    Inhibitor structure-guided design and synthesis of near-infrared fluorescent probes for monoamine oxidase A (MAO-A) and its application in living cells and in vivo

    Z. Yang, W. Li, H. Chen, Q. Mo, J. Li, S. Zhao, C. Hou, J. Qin and G. Su, Chem. Commun., 2019, 55, 2477
    DOI: 10.1039/C8CC10084E

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