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Issue 16, 2019
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Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

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Abstract

Small-molecule-based G4 isolation from genomic DNA has enabled the identification of a total of 51 446 PQSs (potential G-quadruplex sites). Incubating cells with PDP for 3 h to 72 h resulted in the differential expression of a variety of genes, indicating a potential function of G4s in gene regulation.

Graphical abstract: Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

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Publication details

The article was received on 20 Dec 2018, accepted on 24 Jan 2019 and first published on 24 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC10052G
Citation: Chem. Commun., 2019,55, 2269-2272

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    Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

    W. Zeng, F. Wu, C. Liu, Y. Yang, B. Wang, Y. Yuan, J. Wang, Y. Chen, B. Fu, Z. Wu and X. Zhou, Chem. Commun., 2019, 55, 2269
    DOI: 10.1039/C8CC10052G

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