Issue 15, 2019
From the journal:

Chemical Communications

Homogenous deposition of matrix–analyte cocrystals on gold-nanobowl arrays for improving MALDI-MS signal reproducibility†

Weiwei Li, ORCID logo a   Mashooq Khan, ORCID logo a   Haifang Li, ORCID logo a   Ling Lin, ORCID logo *b   Sifeng Mao ORCID logo a  and  Jin-Ming Lin ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Beijing Key Laboratory of Micronalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China
E-mail: jmlin@mail.tsinghua.edu.cn

b CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China
E-mail: linling@nanoctr.cn

Abstract

The non-uniform deposition of matrix–analyte cocrystals and poor ionization are major obstacles in quantitative analysis through MALDI-MS. An Au-nanobowl array was prepared and applied to overcome these limitations, which enabled the quantitative detection of oligonucleotides and polypeptides.

Graphical abstract: Homogenous deposition of matrix–analyte cocrystals on gold-nanobowl arrays for improving MALDI-MS signal reproducibility

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Article information

DOI
https://doi.org/10.1039/C8CC09945F
Article type
Communication
Submitted
18 Dec 2018
Accepted
15 Jan 2019
First published
22 Jan 2019

Chem. Commun., 2019,55, 2166-2169

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Homogenous deposition of matrix–analyte cocrystals on gold-nanobowl arrays for improving MALDI-MS signal reproducibility

W. Li, M. Khan, H. Li, L. Lin, S. Mao and J. Lin, Chem. Commun., 2019, 55, 2166 DOI: 10.1039/C8CC09945F

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