Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

Guilherme Vieira de Castro; Alessio Ciulli

doi:10.1039/C8CC09790A

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Spy vs. spy: selecting the best reporter for ¹⁹F NMR competition experiments†

Guilherme Vieira de Castro

^a and Alessio Ciulli

*^a

Author affiliations

* Corresponding authors

^a Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, UK
E-mail: a.ciulli@dundee.ac.uk

Abstract

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive ¹⁹F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

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Article information

DOI: https://doi.org/10.1039/C8CC09790A
Article type: Communication
Submitted: 10 Dec 2018
Accepted: 27 Dec 2018
First published: 15 Jan 2019
This article is Open Access

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Chem. Commun., 2019,55, 1482-1485

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Spy vs. spy: selecting the best reporter for ¹⁹F NMR competition experiments

G. V. de Castro and A. Ciulli, Chem. Commun., 2019, 55, 1482 DOI: 10.1039/C8CC09790A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications