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Issue 10, 2019
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Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

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Abstract

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

Graphical abstract: Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

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Article information


Submitted
10 Dec 2018
Accepted
27 Dec 2018
First published
15 Jan 2019

This article is Open Access

Chem. Commun., 2019,55, 1482-1485
Article type
Communication

Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

G. V. de Castro and A. Ciulli, Chem. Commun., 2019, 55, 1482
DOI: 10.1039/C8CC09790A

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