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Issue 17, 2019
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Hydrophilic 18F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging

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Abstract

An 18F-labeled trans-5-oxocene (oxoTCO) that is used to construct a PET probe for neurotensin receptor (NTR) imaging through tetrazine ligation is described here. PET probe construction proceeds with 70% RCY based on 18F-oxoTCO and is completed within seconds. The in vivo behaviour of the oxoTCO based PET probe was compared with those of analogous probes that were prepared from 18F-labeled s-TCO and d-TCO tracers. The hydrophilic 18F-oxoTCO probe showed a significantly higher tumor-to-background ratio while displaying comparable tumor uptake relative to the 18F-dTCO and 18F-sTCO derived probes.

Graphical abstract: Hydrophilic 18F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging

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Publication details

The article was received on 09 Dec 2018, accepted on 30 Jan 2019 and first published on 30 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09747J
Citation: Chem. Commun., 2019,55, 2485-2488

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    Hydrophilic 18F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging

    M. Wang, R. Vannam, W. D. Lambert, Y. Xie, H. Wang, B. Giglio, X. Ma, Z. Wu, J. Fox and Z. Li, Chem. Commun., 2019, 55, 2485
    DOI: 10.1039/C8CC09747J

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