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Difluorocarbene-derived trifluoromethylselenolation of benzyl halides

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Abstract

Cu-Promoted difluorocarbene-derived trifluoromethylselenolation of benzyl halides with the Ph3P+CF2CO2/Se/F system is described. Three new carbon–heteroatom bonds, a Se–CF2 bond, SeCF2–F bond, and C–SeCF3 bond, were sequentially formed in the reaction. This work represents the first trifluoromethylselenolation protocol involving an external fluoride for the generation of the key intermediate, CF3Se anion.

Graphical abstract: Difluorocarbene-derived trifluoromethylselenolation of benzyl halides

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Publication details

The article was received on 07 Dec 2018, accepted on 08 Jan 2019 and first published on 08 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09719D
Citation: Chem. Commun., 2019, Advance Article
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    Difluorocarbene-derived trifluoromethylselenolation of benzyl halides

    X. Chen, S. Zhou, J. Lin, Q. Deng and J. Xiao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09719D

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