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Issue 7, 2019
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Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

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Abstract

Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or “isoprenylation” is achieved via hydrogen auto-transfer or 2-propanol-mediated reductive coupling from primary alcohol or aldehyde reactants, respectively. Using this method, asymmetric total syntheses of the terpenoid natural products (+)-ipsenol and (+)-ipsdienol were achieved.

Graphical abstract: Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

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Publication details

The article was received on 07 Dec 2018, accepted on 20 Dec 2018 and first published on 04 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09706B
Citation: Chem. Commun., 2019,55, 981-984
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    Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

    M. Xiang, G. Luo, Y. Wang and M. J. Krische, Chem. Commun., 2019, 55, 981
    DOI: 10.1039/C8CC09706B

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