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Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells

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Abstract

We develop a substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA using the iron-embedded nitrogen-rich carbon nanotubes (FeCN) as the catalytic elements. This biosensor exhibits excellent selectivity and high sensitivity with a detection limit of 8.53 × 10−16 M and a large dynamic range of 6 orders of magnitude. It can be further applied for accurate quantification of microRNA in lung cancer cells.

Graphical abstract: Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells

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Publication details

The article was received on 06 Dec 2018, accepted on 04 Jan 2019 and first published on 04 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09688K
Citation: Chem. Commun., 2019, Advance Article
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    Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells

    L. Cui, M. Wang, B. Sun, S. Ai, S. Wang and C. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09688K

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