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Issue 16, 2019
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Photoactive chelates for radiolabelling proteins

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Abstract

Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.

Graphical abstract: Photoactive chelates for radiolabelling proteins

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Publication details

The article was received on 04 Dec 2018, accepted on 21 Dec 2018 and first published on 21 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09660K
Citation: Chem. Commun., 2019,55, 2257-2260

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    Photoactive chelates for radiolabelling proteins

    L. S. Eichenberger, M. Patra and J. P. Holland, Chem. Commun., 2019, 55, 2257
    DOI: 10.1039/C8CC09660K

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