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Versatile fluorophores for bioimaging applications: π-expanded naphthalimide derivatives with skeletal and appendage diversity

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Abstract

Four novel fluorescent cores bearing a transformable functional group based on a π-expanded naphthalimide including a fused pyranone or furan ring have been prepared. Fluorescent probes LysoSers 13–16 for lysosomal targeting have been tested. Co-localization with a commercial lysosome specific marker confirmed that the LysoSers labeled the lysosomal compartment with high selectivity. The LysoSers show excellent brightness and low toxicity.

Graphical abstract: Versatile fluorophores for bioimaging applications: π-expanded naphthalimide derivatives with skeletal and appendage diversity

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Publication details

The article was received on 04 Dec 2018, accepted on 29 Jan 2019 and first published on 30 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09638D
Citation: Chem. Commun., 2019, Advance Article

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    Versatile fluorophores for bioimaging applications: π-expanded naphthalimide derivatives with skeletal and appendage diversity

    M. Havlík, V. Talianová, R. Kaplánek, T. Bříza, B. Dolenský, J. Králová, P. Martásek and V. Král, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09638D

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