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Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

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Abstract

c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.

Graphical abstract: Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

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Publication details

The article was received on 01 Dec 2018, accepted on 21 Dec 2018 and first published on 26 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09558B
Citation: Chem. Commun., 2019, Advance Article
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    Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

    L. Qian, S. Pan, J. Lee, J. Ge, L. Li and S. Q. Yao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09558B

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