Issue 16, 2019
From the journal:

Chemical Communications

Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells†

Qian Cheng,a   Kun-Xu Teng,b   Yuan-Fu Ding,a   Ludan Yue, ORCID logo a   Qing-Zheng Yang ORCID logo *b  and  Ruibing Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, Taipa, China
E-mail: rwang@umac.mo

b Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China
E-mail: qzyang@bnu.edu.cn

Abstract

Paclitaxel-loaded nanoparticles based on a bispillar[5]arene compound were successfully developed using a microemulsion method for the first time. The nanoparticles exhibited dual stimuli-responsiveness towards both spermine and glutathione, allowing precisely selective drug release in lung cancer cells that overexpress both stimuli.

Graphical abstract: Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

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Article information

DOI
https://doi.org/10.1039/C8CC09432B
Article type
Communication
Submitted
27 Nov 2018
Accepted
29 Jan 2019
First published
29 Jan 2019

Chem. Commun., 2019,55, 2340-2343

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Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells

Q. Cheng, K. Teng, Y. Ding, L. Yue, Q. Yang and R. Wang, Chem. Commun., 2019, 55, 2340 DOI: 10.1039/C8CC09432B

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