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Issue 6, 2019
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Double asymmetric hydrogenation of conjugated dienes: a self-breeding chirality route for C2 symmetric 1,4-diols

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Abstract

The synthesis and double asymmetric hydrogenation of (Z,Z)-1,3-diene-1,4-diyl diacetates is described. In this reaction C2/meso ratios up to 85 : 15 and enantioselectivities up to 97% ee have been achieved. As the hydrogenation products can be converted into chiral 1,4-diols, key starting materials for the preparation of the best catalysts used, this catalytic system enables a self-breeding chirality process.

Graphical abstract: Double asymmetric hydrogenation of conjugated dienes: a self-breeding chirality route for C2 symmetric 1,4-diols

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Publication details

The article was received on 26 Nov 2018, accepted on 11 Dec 2018 and first published on 12 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09391A
Citation: Chem. Commun., 2019,55, 786-789
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    Double asymmetric hydrogenation of conjugated dienes: a self-breeding chirality route for C2 symmetric 1,4-diols

    F. León, J. Francos, J. López-Serrano, S. E. García-Garrido, V. Cadierno and A. Pizzano, Chem. Commun., 2019, 55, 786
    DOI: 10.1039/C8CC09391A

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