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Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum

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Abstract

Integrating molecular networking and 1H NMR techniques successfully enabled the discovery of three new cycloheptapeptides, asperversiamides A–C (1–3). Their complete structures were further confirmed by total synthesis. All three compounds exhibited potent inhibitory activity against Mycobacterium marinum.

Graphical abstract: Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum

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Publication details

The article was received on 24 Nov 2018, accepted on 27 Dec 2018 and first published on 28 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09347D
Citation: Chem. Commun., 2019, Advance Article
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    Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum

    X. Hou, T. Liang, Z. Guo, C. Wang and C. Shao, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09347D

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