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Issue 14, 2019
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Destabilization of DNA through interstrand crosslinking by UO22+

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Abstract

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO22+-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO22+ binding.

Graphical abstract: Destabilization of DNA through interstrand crosslinking by UO22+

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Publication details

The article was received on 23 Nov 2018, accepted on 02 Jan 2019 and first published on 02 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09329F
Chem. Commun., 2019,55, 2015-2018

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    Destabilization of DNA through interstrand crosslinking by UO22+

    A. Rossberg, T. Abe, K. Okuwaki, A. Barkleit, K. Fukuzawa, T. Nakano, Y. Mochizuki and S. Tsushima, Chem. Commun., 2019, 55, 2015
    DOI: 10.1039/C8CC09329F

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