Destabilization of DNA through interstrand crosslinking by UO22+

André Rossberg; Takaya Abe; Koji Okuwaki; Astrid Barkleit; Kaori Fukuzawa; Tatsuya Nakano; Yuji Mochizuki; Satoru Tsushima

doi:10.1039/C8CC09329F

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Destabilization of DNA through interstrand crosslinking by UO₂²⁺†

André Rossberg,^a Takaya Abe,^b Koji Okuwaki,^b Astrid Barkleit,

^a Kaori Fukuzawa,^c Tatsuya Nakano,^d Yuji Mochizuki

^be and Satoru Tsushima

*^af

Author affiliations

* Corresponding authors

^a Institute of Resource Ecology, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
E-mail: s.tsushima@hzdr.de

^b Department of Chemistry and Research Center for Smart Molecules, Rikkyo University, Tokyo, Japan

^c Department of Physical Chemistry, Hoshi University, Tokyo, Japan

^d Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan

^e Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

^f Tokyo Tech World Research Hub Initiative (WRHI), Tokyo Institute of Technology, Tokyo, Japan

Abstract

UO₂²⁺ was shown to form an interstrand crosslink between two different strands of a single DNA molecule. This crosslink hardly affected the hydrogen bonds between nucleobase pairs but destabilized the π–π stacking between the two nucleobases in the vicinity of UO₂²⁺-bound phosphate. Thereby, the fragility of the DNA backbone increased upon UO₂²⁺ binding.

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Article information

DOI: https://doi.org/10.1039/C8CC09329F
Article type: Communication
Submitted: 23 Nov 2018
Accepted: 02 Jan 2019
First published: 02 Jan 2019

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Chem. Commun., 2019,55, 2015-2018

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Destabilization of DNA through interstrand crosslinking by UO₂²⁺

A. Rossberg, T. Abe, K. Okuwaki, A. Barkleit, K. Fukuzawa, T. Nakano, Y. Mochizuki and S. Tsushima, Chem. Commun., 2019, 55, 2015 DOI: 10.1039/C8CC09329F

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Chemical Communications