Issue 14, 2019
From the journal:

Chemical Communications

Visualizing telomerase activity for tumour identification by hybridization-triggered ratiometric fluorescence†

Manli Zheng,a   Ruilong Zhang,a   Xiaohe Tian, ORCID logo a   Zhengjie Liu*a  and  Zhongping Zhang ORCID logo a  

* Corresponding authors

a School of Chemical and Chemical Engineering, Institutes of Physical Science and Information Technology, School of Life Science, Anhui University, Hefei, Anhui, China
E-mail: zjliu@ahu.edu.cn

Abstract

Telomerase is repressed stringently in normal cells but highly activated in tumours to maintain their uncontrollable growth. We report a ratiometric fluorescence strategy for visualising telomerase activity for tumour identification. Using our strategy, tumour cells and tissues can be differentiated from normal cells and tissues by the naked eye.

Graphical abstract: Visualizing telomerase activity for tumour identification by hybridization-triggered ratiometric fluorescence

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Article information

DOI
https://doi.org/10.1039/C8CC09257E
Article type
Communication
Submitted
21 Nov 2018
Accepted
14 Jan 2019
First published
14 Jan 2019

Chem. Commun., 2019,55, 2035-2038

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Visualizing telomerase activity for tumour identification by hybridization-triggered ratiometric fluorescence

M. Zheng, R. Zhang, X. Tian, Z. Liu and Z. Zhang, Chem. Commun., 2019, 55, 2035 DOI: 10.1039/C8CC09257E

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