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Issue 8, 2019
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Photo-regulatable DNA isothermal amplification by template-mediated ligation

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Abstract

By combining azobenzene-tethered oligonucleotides as modulators and poly(L-lysine)-graft-dextran (PLL-g-Dex), a chaperone polymer, to facilitate strand displacement, we successfully developed a photo-regulatable DNA isothermal amplification method. By alternating UV and visible irradiation, linear amplification was achieved. The method enables photo-regulatability and mismatch discrimination in linear amplification of the DNA target.

Graphical abstract: Photo-regulatable DNA isothermal amplification by template-mediated ligation

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Publication details

The article was received on 20 Nov 2018, accepted on 17 Dec 2018 and first published on 19 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09218D
Citation: Chem. Commun., 2019,55, 1080-1083

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    Photo-regulatable DNA isothermal amplification by template-mediated ligation

    B. Cheng, H. Kashida, N. Shimada, A. Maruyama and H. Asanuma, Chem. Commun., 2019, 55, 1080
    DOI: 10.1039/C8CC09218D

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